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 Are Chemical Reactions dependent on  reagent orientation?

Indirect Evidence:  yes
     "Common Sense"  (dates back to ancient Greece)
     "Chemical Intuition" (more modern version of above)
      Molecular Structure
           Electron & X-ray diffraction
           Spectroscopy
      Reactivity
           Walden inversion
           Kinetic steric factors

Direct Evidence:  YES! 
     We orient dipolar molecules in molecular beams and compare the reactivity at the positive end and the negative end.
    (more coming--this research supported by the NSF)