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Courtesy of Marie Curie Research Institute, Molecular Motors Group

Mechanisms of Motor Protein Transport

A group of catalytic proteins, known as motor proteins, such as kinesins, dyneins, myosins, DNA and RNA polymerases operate in biological cells by consuming energy provided by ATP hydrolysis. They play crucial roles in cell division, cellular transport, muscle contraction and genetic transcription. Current experimental techniques allow measurements of biochemical and mechanical properties of motor proteins with single-molecule precision. However, the main fundamental question related to motor proteins - how the chemical energy is transformed into mechanical motion - is still unanswered. We are developing stochastic models of the motion of motor proteins which take into consideration the biochemical complexity of these processes. Our theoretical methods will be used to describe existing and future experiments on motor protein transport.

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